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Vaccine slashes chance of long Covid, says study, but risk remains
In the unvaccinated group, 10.42 out of 100 people early in the pandemic (before vaccines were available) had developed long Covid one year after being infected. In the Delta variant era (defined as June 19 through Dec. 18, 2021), 9.51 out of 100 unvaccinated people were diagnosed with long Covid, compared to 5.34 out of 100 vaccinated people. When the current Omicron era began (Dec. 19, 2021), the gap widened: 7.76 out of 100 unvaccinated people but only 3.5 out of 100 vaccinated people acquired long Covid.
“Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases | Pritzker School of Molecular Engineering | The University of Chicago
The inverse vaccine, described in Nature Biomedical Engineering, takes advantage of how the liver naturally marks molecules from broken-down cells with “do not attack” flags to prevent autoimmune reactions to cells that die by natural processes. PME researchers coupled an antigen — a molecule being attacked by the immune system— with a molecule resembling a fragment of an aged cell that the liver would recognize as friend, rather than foe. The team showed how the vaccine could successfully stop the autoimmune reaction associated with a multiple-sclerosis-like disease.
“In the past, we showed that we could use this approach to prevent autoimmunity,” said Jeffrey Hubbell, the Eugene Bell Professor in Tissue Engineering and lead author of the new paper. “But what is so exciting about this work is that we have shown that we can treat diseases like multiple sclerosis after there is already ongoing inflammation, which is more useful in a real-world context.”
FDA vaccine advisers 'disappointed' and 'angry' that early data about new Covid-19 booster shot wasn't presented for review last year | CNN
It found that 1.9% of the study participants who received the original booster became infected. Among those who got the updated bivalent vaccine – the one that scientists hoped would work better – a higher percentage, 3.2%, became infected. Both versions of the shot were found to be safe.
This infection data was far from complete. The number of study subjects who became infected was very small, and both the patients and the researchers were aware of who was getting the original shot and who was getting the new booster.
Despite these imperfections, the data was included in a preprint study that was posted online in June, again in September in an FDA document and then later that month in a top medical journal – and advisers to the FDA and the CDC said the data should have been shared with them, too.
FDA vaccine advisers 'disappointed' and 'angry' that early data about new Covid-19 booster shot wasn't presented for review last year | CNN
“I was angry to find out that there was data that was relevant to our decision that we didn’t get to see,” said Dr. Paul Offit, a member of the Vaccines and Related Biological Products Advisory Committee, a group of external advisers that helps the FDA make vaccine decisions. “Decisions that are made for the public have to be made based on all available information – not just some information, but all information.”
How Some Parents Changed Their Politics in the Pandemic - The New York Times
In interviews, 27 parents who called themselves anti-vaccine and anti-mask voters described strikingly similar paths to their new views. They said they had experienced alarm about their children during pandemic quarantines. They pushed to reopen schools and craved normalcy. They became angry, blaming lawmakers for the disruption to their children’s lives.
Many congregated in Facebook groups that initially focused on advocating in-person schooling. Those groups soon latched onto other issues, such as anti-mask and anti-vaccine messaging. While some parents left the online groups when schools reopened, others took more extreme positions over time, burrowing into private anti-vaccine channels on messaging apps like WhatsApp and Telegram.
Eventually, some began questioning vaccines for measles and other diseases, where inoculations have long been proven effective. Activists who oppose all vaccines further enticed them by joining online parent groups and posting inaccurate medical studies and falsehoods.
How Some Parents Changed Their Politics in the Pandemic - The New York Times
Ms. Longnecker and her fellow objectors are part of a potentially destabilizing new movement: parents who joined the anti-vaccine and anti-mask cause during the pandemic, narrowing their political beliefs to a single-minded obsession over those issues. Their thinking hardened even as Covid-19 restrictions and mandates were eased and lifted, cementing in some cases into a skepticism of all vaccines.
Nearly half of Americans oppose masking and a similar share is against vaccine mandates for schoolchildren, polls show. But what is obscured in those numbers is the intensity with which some parents have embraced these views. While they once described themselves as Republicans or Democrats, they now identify as independents who plan to vote based solely on vaccine policies.
Protective immunity against SARS-CoV-2 could last eight months or more: Why declining antibodies don't spell disaster for long-lasting immunity -- ScienceDaily
"It is possible that immune memory will be similarly long lasting similar following vaccination, but we will have to wait until the data come in to be able to tell for sure," says Weiskopf. "Several months ago, our studies showed that natural infection induced a strong response, and this study now shows that the responses lasts. The vaccine studies are at the initial stages, and so far have been associated with strong protection. We are hopeful that a similar pattern of responses lasting over time will also emerge for the vaccine-induced responses."
Covid-19 Vaccines With ‘Minor Side Effects’ Could Still Be Pretty Bad | WIRED
The press release for Monday’s publication of results from the Oxford vaccine trials described an increased frequency of “minor side effects” among participants. A look at the actual paper, though, reveals this to be a marketing spin that has since been parroted in media reports. (The phrases “minor side effects” or “only minor side effects” appeared in writeups from The New York Times, The Wall Street Journal and Reuters, among other outlets.) Yes, mild reactions were far more common than worse ones. But moderate or severe harms—defined as being bad enough to interfere with daily life or needing medical care—were common too. Around one-third of people vaccinated with the Covid-19 vaccine without acetaminophen experienced moderate or severe chills, fatigue, headache, malaise, and/or feverishness. Close to 10 percent had a fever of at least 100.4 degrees, and just over one-fourth developed moderate or severe muscle aches. That’s a lot, in a young and healthy group of people—and the acetaminophen didn’t help much for most of those problems.
Protective Effect of Hand-Washing and Good Hygienic Habits Against Seasonal Influenza
Compared with the poorest hand-washing score of 0 to 3, odds ratios of influenza infection decreased progressively from 0.26 to 0.029 as hand-washing score increased from 4 to the maximum of 9 (P < 0.001). Compared with the poorest hygienic habit score of 0 to 2, odds ratios of influenza infection decreased from 0.10 to 0.015 with improving score of hygienic habits (P < 0.001). Independent protective factors against influenza infection included good hygienic habits, higher hand-washing score, providing soap or hand cleaner beside the hand-washing basin, and receiving influenza vaccine.
