Recent quotes:

Screening + Drug Treatment = Increase in Veteran Suicides - Mad In America

There is clear evidence that SSRIs and SNRI antidepressants can provoke suicidal impulses and acts in some users, and the reason is well known. SSRIs and other antidepressants can stir extreme restlessness, agitation, insomnia, severe anxiety, mania and psychotic episodes. The agitation and anxiety, which is clinically described as akathisia, may reach “unbearable” levels, and akathisia is known to be associated with suicide and acts of violence, including homicide.

DEMAND CHEMICAL IMBALANCE RETRACTION: Round One: The Most Absurd "Chemical Imbalance" Quote

There's almost 200 quotes on this page so far. In efforts to find the most preposterous I need your help. Over the next few weeks I'll be wanting you to vote. There will be a cut-off point for each post. I have included the Twitter/Facebook link for each of the individuals. If you want to ask them to join in then please feel free to contact them. This will give them an opportunity to retract their claim or not, as the case may be.

Richard Smith: Psychiatry in crisis? - The BMJ

Dutch psychiatrists, it was explained to me, are feeling vulnerable because there are too many of them. They have two treatments to offer–drugs and psychotherapy. But the Netherlands has many clinical psychologists, and they have taken over the psychotherapy. Psychiatrists are left with drugs and anxiety about their future.

Why cancer screening has never been shown to “save lives”—and what we can do about it | The BMJ

Discrepancies between disease specific and overall mortality were found in direction or magnitude in seven of 12 randomised trials of cancer screening.8 Despite reductions in disease specific mortality in the majority of studies, overall mortality was unchanged or increased. In cases where both mortality rates were reduced the improvement was larger in overall mortality than in disease specific mortality. This suggests an imbalance in non-disease specific deaths, which warrants examination and explanation.

Evolution of systems

Food in New York improves from bankruptcy to bankruptcy, rather than the chefs individual learning curves –compare the food quality in mortal restaurants to that in an immortal governmental cafeteria. And in the absence of the filtering of skin in the game, the mechanisms of evolution fail: if someone else dies in your stead, the built up of asymmetric risks and misfitness will cause the system to eventually blow-up.

A pill to fight alcoholism causes an uproar in France

Among the issues they cited was the ANSM decision to approve baclofen before the second study was publicly available. Even before publication, the academics noted the trial sponsor — the Public Assistance Hospital in Paris — touted results in a press release. The hospital also sold study data to Ethypharm, a small company that sought regulatory approval to market the drug, although this was not disclosed in the paper. Curiously, Ethypharm also performed the analysis that was the basis for the ANSM decision. When the Bacloville study was finally published last December, the group of researchers discovered an unexplained change in the primary outcome, a practice that is frowned upon because it can suggest an attempt to achieve desired results. The researchers contend the change in outcomes made it harder to analyze what, if any, difference baclofen had on patients, leading to a bias in favor of the drug. “Biased trials lead to biased decisions, and biased decisions mean that people get treatment that doesn’t work, possibly don’t get treatment that does work, can be harmed by treatment and it costs the health care system more,” said Joel Lexchin, a professor of family and community medicine at the University of Toronto, and one of the researchers who have criticized the Bacloville study.

Why Doctors Are Bad At Stats — And How That Could Affect Your Health

Gerd and his team have explored whether medical professionals understand the statistics measures actually needed to prove that a cancer screening programme saves lives. This is a classic problem in health statistics. What clinicians need to compare is mortality rates, not 5-year survival rates. The mortality rate tells the number of deaths in a period of time. In contrast, the 5-year survival rate only tells how many people live 5 years after the day they have been diagnosed with cancer. Some screening programmes can diagnose people earlier — which can increase those ‘5-year survival rates’ — without making them live any longer.

A brief history of medical statistics and its impact on reproducibility.

By failing to address the structurally driven deficits in scientific and statistical thinking already apparent decades earlier, and then amplifying them with professional incentives to produce more and more research (grossly mismeasured by papers published), medical research had become a scandal. Altman concluded that “We need less research, better research, and research done for the right reasons.” This is, in my opinion, the most important sentence ever written about medical research, but it fell on deaf ears. How do I know this? A decade or so later, the Lancet published a special issue on research waste, which made the case that medical research costing billions of dollars each year is wasted due to things like poor research questions, flawed study designs, erroneous statistical analyses, and clumsy research reports (15).

Using Open Questions to Understand 650 People’s Experiences With Antipsychotic Drugs | Schizophrenia Bulletin | Oxford Academic

In this study, 650 people, from 29 countries, responded, in an online survey, to “Overall in my life antipsychotic medications have been _____?” and “Is there anything else you would like to say, or emphasise, about your experiences with antipsychotic drugs?” Of the total participants, 14.3% were categorized as reporting purely positive experiences, 27.9% had mixed experiences, and 57.7% reported only negative ones.

How many of 1829 antidepressant users report withdrawal effects or addiction? - PubMed - NCBI

A total of 1829 New Zealanders who had been prescribed antidepressants completed an online survey; 44% had been taking antidepressants for more than 3 years and were still taking them. Withdrawal effects when stopping medication were reported by 55%, and addiction by 27%. Paroxetine had particularly high rates of withdrawal symptoms.

Electronic Health Records Vendor to Pay $155 Million to Settle False Claims Act Allegations | OPA | Department of Justice

or example, in order to pass certification testing without meeting the certification criteria for standardized drug codes, the company modified its software by “hardcoding” only the drug codes required for testing. In other words, rather than programming the capability to retrieve any drug code from a complete database, ECW simply typed the 16 codes necessary for certification testing directly into its software. ECW’s software also did not accurately record user actions in an audit log and in certain situations did not reliably record diagnostic imaging orders or perform drug interaction checks. In addition, ECW’s software failed to satisfy data portability requirements intended to permit healthcare providers to transfer patient data from ECW’s software to the software of other vendors. As a result of these and other deficiencies in its software, ECW caused the submission of false claims for federal incentive payments based on the use of ECW’s software.

Texas Psychiatrist Karen Wagner Under Scrutiny - AHRPAHRP

co-authored the notorious, ghostwritten Paxil pediatric study #329, whose lead author, Martin Keller, MD, was replaced last month as chairman of psychiatry at Brown University. The Glaxo-paid authors of study #329 helped the company promote the myth that Paxil was "safe and effective" for use in children as early as 1998: in a poster presentation, Dr. Wagner claimed "The results of this study demonstrate the safety ofparoxetine in the treatment of adolescent depression. Side effects were modest with paroxetine." [2]  But internal Glaxo emails show the data from pediatric Paxil trials were negative.

Health care data-sharing rules touch off intense lobbying fight - POLITICO

But many in the industry say they have patients’ best interests at heart in asking for increased privacy protections as part of the rule. “The primary beneficiaries of this rule are venture capitalists and others taking advantage of patient data,” said Epic executive Sumit Rana in an interview Monday. Disclosing patient records in unfettered fashion can hurt patients, he said. The rule’s promise of eased access to a patient’s entire medical record through an interface is an invitation for app developers — well-funded and sketchy alike — to pick over patient data and commercialize it, he said. In that, he said the proposed rules “go well beyond the 21st Century Cures Act,” which sought to modernize health care with better use of IT.

FDA and NIH let clinical trial sponsors keep results secret and break the law | Science | AAAS

The University of Texas MD Anderson Cancer Center and the Mayo Clinic both failed to report results on time, or at all, in about two-thirds of their trials. Yale University failed to do so in 84% of its trials. NIH’s own institutes also had a bad record. They are directly responsible for reporting results when they sponsor studies done by agency staff or some grantees, and the top four NIH institute sponsors, taken together, reported results late or not at all in more than six of every 10 trials Science looked at. Contacted for comment, none of the institutions disputed the findings of this investigation. In all 4768 trials Science checked, sponsors violated the reporting law more than 55% of the time. And in hundreds of cases where the sponsors got credit for reporting trial results, they have yet to be publicly posted because of quality lapses flagged by ClinicalTrials.gov staff (see sidebar).

For Her Head Cold, Insurer Coughed Up $25,865 | Kaiser Health News

The third reason for the high bill may be the connection between the lab and Kasdan’s doctor. Kasdan’s bill shows that the lab service was provided by Manhattan Gastroenterology, which has the same phone number and locations as her doctor’s office.

Doctors Prescribe More of a Drug If They Receive Money from a Pharma Company Tied to It — ProPublica

“If there are physicians out there that deny that there is a relationship, they are starting to look more and more like climate deniers in the face of the growing evidence,” said Aaron Kesselheim, a professor of medicine at Harvard Medical School and an expert in pharmaceutical costs and regulation. “The association is consistent across the different types of payments. It’s also consistent across numerous drug specialties and drug types, across multiple different fields of medicine. And for small and large payments. It’s a remarkably durable effect. No specialty is immune from this phenomenon.”

Doctors Prescribe More of a Drug If They Receive Money from a Pharma Company Tied to It — ProPublica

On average, across all drugs, providers who received payments specifically tied to a drug prescribed it 58% more than providers who did not receive payments.

What These Medical Journals Don’t Reveal: Top Doctors’ Ties to Industry - The New York Times

“The system is broken,” said Dr. Mehraneh Dorna Jafari, an assistant professor of surgery at the University of California, Irvine, School of Medicine. She and her colleagues published a study in August that found that, of the 100 doctors who received the most compensation from device makers in 2015, conflicts were disclosed in only 37 percent of the articles published in the next year. “The journals aren’t checking and the rules are different for every single thing.”

Gilead, LGBTQ community ask Facebook to remove misleading PrEP ads | FiercePharma

More than 50 organizations involved with LGBTQ advocacy, public health and HIV/AIDS prevention have co-signed a letter to Facebook Chairman and CEO Mark Zuckerberg asking him to take down “dangerous and misleading” ads on Facebook and Instagram. By not doing anything, the social media companies are harming public health, the groups contend. Gilead, which makes HIV prevention drugs Truvada and Descovy, agrees with the effort and applauds the organizations standing up for their communities, it said. “We join calls to have any misleading advertisements related to Gilead’s HIV medications removed from Facebook," it added in a statement.

Announcing ICD-10-CM and RxNorm Ontology Linking for Amazon Comprehend Medical

Medical ontologies, such as ICD-10, make it possible to classify unstructured medical information into standardized codes that downstream healthcare applications, such as revenue cycle management tools (medical coding) can read. Amazon Comprehend Medical ICD-10-CM RXNorm Ontology Linking extracts medical condition and medication entities from medical text and links them to the relevant ICD-10-CM and RXNorm concepts respectively.   Using Amazon Comprehend Medical ICD-10-CM and RXNorm Ontology Linking APIs, developers can quickly and accurately extract codes (e.g. “R51” as the ICD-10-CM code for headache) from a variety of data sources, such as doctor’s notes or patient health records. Our deep learning approach to ontology linking provides much higher accuracy than existing rules-based systems by understanding the context each entity is found in.

dmca/2019-11-08-abbott.md at master · github/dmca · GitHub

It has come to Abbott’s attention that a software project titled “Libre2-patched-App” has been uploaded to GitHub, Inc.’s (“GitHub”) website and creates unauthorized derivative works of Abbott’s LibreLink program (the “Infringing Software”). The Infringing Software is available at https://github.com/user987654321resu/Libre2-patched-App. In addition to offering the Infringing Software, the project provides instructions on how to download the Infringing Software, circumvent Abbott’s technological protection measures by disassembling the LibreLink program, and use the Infringing Software to modify the LibreLink program.

New York Union Blames Out-of-Network Doctors for Millions in Costs - Bloomberg

“That raised a question for us as to whether there has been, implicitly or explictly, a business decision by Northwell to allow doctors to be out-of-network and to bill at really high rates,” Rothstein said. Northwell insists the answer is no. Outside doctors that have admitting privileges at Northwell bill the health plan separately and aren’t authorized to use Northwell’s name on their bills, Aviles said. “Legally we can’t tell another corporation what to do and how much to bill,” Aviles said. The union health fund said a handful of provider groups accounted for a disproportionate share of the  out-of-network bills. It declined to identify those groups but one provider-group billed 100% of its claims at Northwell as out-of-network, according to 32BJ.

Abbott Labs kills free tool that lets you own the blood-sugar data from your glucose monitor, saying it violates copyright law / Boing Boing

First, they say that creating a tool that interoperates with the Freestyle Libre's data is a copyright infringement, because the new code is a derivative work of Abbott's existing product. But code that can operate on another program's data is not a derivative work of the first program -- just because Apple's Pages can read Word docs, it doesn't mean that Pages is a derivative of MS Office. In addition, as Diabettech points out, EU copyright law explicitly contains an exemption for reverse engineering in order to create interoperability between medical devices (EU Software Directive, Article 6). More disturbing is Kirkland/Abbott's claim that the project violates Section 1201 of the Digital Millennium Copyright Act, which prohibits bypassing "access controls" for copyrighted works. Factual data (like your blood sugar levels) are not copyrightable -- and if they were, you would hold that copyright. It's your blood. What's more, DMCA 1201 also contains an interoperability exemption.

How have healthcare prices grown in the U.S. over time? - Peterson-Kaiser Health System Tracker

In 2016, while the average price paid by large employers for an admission for a full knee replacement was $34,063, 25 percent of admissions had a price of $24,734 or less and another 25 percent had prices higher than $39,786. […]Ten percent of admissions had prices in excess of $52,181 (53% above the average). For laparoscopic appendectomies, the average price paid for an admission was $20,192 in 2016; 25 percent of admissions had prices of $12,088 or less while another 25% had prices of over $24,847. Ten percent of admissions had prices in excess of $35,308 (75% above the average).

Four Reasons Drugs Are Expensive, Of Which Two Are False

Thus there is a lot of deliberate obfuscation of the real prices, net of rebates, discounts, clawbacks, budget caps, etc., that health systems actually pay. Elastic also loosens when there are barriers to trade. The European Union is a free trade zone. Therefore, if one sells pills into Greece, where prices are low, it is more profitable overall to make sure they are in Greek language-only packaging, in Greek language-only blister packs, with something obvious and Greek printed on the pills, and – if possible – in a dose that is subtly different from any dose that can be legally sold in the UK or Germany. This makes it tedious to repackage the pills, before shipping them to parts of the European Union where they compete with similar pills that the manufacturer is selling a higher price: Tedious but not impossible, as German friends taking re-exported Greek drugs recently told me.

Four Reasons Drugs Are Expensive, Of Which Two Are False

From the company’s perspective, the drug was much too cheap. Had Sanofi applied the cancer price to the multiple sclerosis dose, it would have been charging around $6,000 per year when multiple sclerosis drugs had annual prices closer to $60,000. So Sanofi withdrew Campath from commercial sale in late 2012 and re-launched it in 2013 in Europe and in 2014 in the US with a new name, Lemtrada, a new multiple sclerosis indication, and a list price rise of over one thousand – yes, one thousand – percent. The temporary withdrawal outraged neurologists who had been using Campath off-label for years, but who could not get the drug for their patients until the re-launch.