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High-intensity Exercise Can Reverse Neurodegeneration in Parkinson’s Disease < Yale School of Medicine
Following the six-month program, brain imaging showed a significant increase in both the neuromelanin and DAT signals in the substantia nigra. This suggests that high-intensity exercise not only slowed down the neurodegenerative process, but also helped the dopaminergic system grow healthier.
“Where we would have ordinarily expected to see a decline in the DAT and neuromelanin signals, we saw an increase,” says Bart de Laat, PhD, associate professor adjunct in psychiatry and the study’s first author. “We had hoped to see that the neurodegeneration would not progress as quickly or stop temporarily, but instead we saw an increase in nine out of 10 people. That was remarkable.”
The study highlights the importance of including an exercise regimen as part of one’s Parkinson’s treatment plan. “The medications we have available are only for symptomatic treatment. They do not change the disease course,” says Tinaz. “But exercise seems to go one step beyond and protect the brain at the neuronal level.”
Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus | Science
Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents.