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Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis | Journal of Neurology, Neurosurgery & Psychiatry
Forty-two pwMS were randomised, 34 completed the study (17/group). Leptin serum levels at 12 weeks were significantly lower in the iCR versus the control group (mean decrease −6.98 µg/dL, 95% CI: −28.02 to 14.06; p=0.03). Adherence to iCR was 99.5% and 97.2% at 6 and 12 weeks, respectively, and no serious AEs were reported. An increase in blood CD45RO+ regulatory T-cell numbers was seen after 6 weeks of iCR. Exploratory cognitive testing demonstrated a significant improvement in the Symbol Digit Modality Test Score in the iCR group at 12 weeks.
Intermittent Fasting Shows Promise in Multiple Sclerosis | MedPage Today
Intermittent calorie restriction lowered leptin levels in a small trial of relapsing-remitting multiple sclerosis (MS).
Leptin may have a pathogenic role in MS.
Intermittent calorie restriction also showed cognitive benefits in an exploratory analysis.
Living in a sunnier climate as a child and young adult may reduce risk of MS: Getting more summer sun also associated with lower risk -- ScienceDaily
They found that women who lived in sunnier climates with the highest exposure to UV-B rays had 45 percent reduced risk of developing MS across all pre-MS onset age groups when compared to those living in areas with the lowest UV-B ray exposure. When looking at specific age groups, those who lived in areas with the highest levels of UV-B rays between ages 5 to 15 had a 51 percent reduced risk of MS compared to the lowest group. A total of 33 of 147 people with MS, or 22 percent, had high exposure at ages 5 to 15, while 61 people, or 41 percent, had low exposure. In addition, those who spent more time outdoors in the summer at ages 5 to 15 in locations where exposure to UV-B rays was the highest had a 55 percent reduced risk of developing the disease compared to those in the lowest-exposure group.
North of 37 degrees double MS risk
living at a latitude above 37° increased the risk of developing MS throughout life by greater than 100%.
