Recent quotes:

Book Review: ‘Ending Medical Reversal’ Laments Flip-Flopping - The New York Times

“Often the study of the study of how therapies should work is much more extensive and comes before the study of whether therapies do work,” the authors write. Thus a medical culture based on “should work” rather than “does work” is condemned to constantly correct itself when the science is finally evaluated for outcomes that matter. To fix this constant backtracking would require nothing less than a revolution in how doctors are trained, with an emphasis on the proven and practical rather than the theoretical. (It would also require a second revolution in how doctors practice, with less prestige and remuneration for coming up with new ideas and more for validating old ones.)

Seeking the Productive Life: Some Details of My Personal Infrastructure—Stephen Wolfram Blog

Could one actually work like this, typing and everything? After my “heart-rate discovery” I decided I had to try it. I thought I’d have to build something myself, but actually one can just buy “walking desks”, and so I did. And after minor modifications, I discovered that I could walk and type perfectly well with it, even for a couple of hours. I was embarrassed I hadn’t figured out such a simple solution 20 years ago. But starting last fall—whenever the weather’s been good—I’ve tried to spend a couple of hours of each day walking outside like this:

Quantum science turns social -- ScienceDaily

Why could players without any formal training in experimental physics manage to find surprisingly good solutions? One hint came from an interview with a top-player, a retired Italian microwave systems engineer. He said, that for him participating in the Alice Challenge reminded him a lot of his previous job as an engineer. He never attained a detailed understanding of microwave systems but instead spent years developing an intuition of how to optimize the performance of his "black-box." "We humans may develop general optimization skills in our everyday work life that we can efficiently transfer to new settings. If this is true, any research challenge can in fact be turned into a citizen science game," said Jacob Sherson, head of the ScienceAtHome project at Aarhus University. It still seems incredible that untrained amateurs using an unintuitive game interface outcompete expert experimentalists. One answer may lie in an old Herbert Simon quote: "Solving a problem simply means representing it so as to make the solution transparent."

The happiness project | Science

In 2010, cancer biologist Lei Cao—inspired by a family member who had died of cancer—wondered whether she could combat it by looking beyond drugs or genes. Her team at OSU created a 1-square-meter enclosure filled with so many mazes, running wheels, and bright red, blue, and orange igloos that her daughter dubbed it “Disneyland for Mice.” <img class="fragment-image" src="https://d2ufo47lrtsv5s.cloudfront.net/content/sci/359/6376/624/F3.medium.gif"/> A fish at the University of Michigan in Ann Arbor gets to choose between an empty tank and one filled with marbles. PHOTO: AUSTIN THOMASON/MICHIGAN PHOTOGRAPHY When injected with cancer cells, animals housed there developed tumors 80% smaller than those in control mice, or no tumors at all. Cao even discovered a possible mechanism: A stimulating environment seemed to activate the brain's hypothalamus, which regulates hormones that affect everything from mood to cancer proliferation. “We showed that there's a hard science behind enrichment,” she says. “You can't just treat the body—you have to treat the mind.”

rat enrichment

Inspired by research that showed enrichment could spark the growth of new neurons, he provided the rodents with cardboard for making nests, brightly colored balls for play, and ladders and ropes to climb. Remarkably, the animals were much slower to develop symptoms of a Huntington-like disease than their counterparts in standard housing—the first demonstration that enrichment could significantly influence neurological disorders.

The happiness project | Science

Today, lab mice live in shoebox-size cages hundreds of thousands of times smaller than their natural ranges, and rats can't forage or even stand upright. Both spend their days blasted by ventilation and bright fluorescent lighting that disrupts their day-night cycles. “We're doing the exact opposite of what we should be doing to make these animals happy,” Garner says. Lab animals tend to be obese, have weak immune systems, and develop cancer—all before scientists do any experiments on them.