henry copeland @hc

Creating https://t.co/yaIkIOcF20, an online toolkit the average person can use for personal (n-of-1) experiments. Way back when: Y84, bond trader, journalist.

Recent quotes:

Drug Makers Are Advocacy Group’s Biggest Donors - The New York Times

Slides from a presentation delivered by the salesmen show that the company urged the alliance to resist state efforts to limit access to mental health drugs. “Solutions: Play Hard Ball,” one slide was titled. “Hold policy makers accountable for their decisions in media and in election,” it continued. The alliance’s own slides concluded by saying, “We appreciate AstraZeneca’s strong support of NAMI.”

Drug Makers Are Advocacy Group’s Biggest Donors - The New York Times

But according to investigators in Mr. Grassley’s office and documents obtained by The New York Times, drug makers from 2006 to 2008 contributed nearly $23 million to the alliance, about three-quarters of its donations. Even the group’s executive director, Michael Fitzpatrick, said in an interview that the drug companies’ donations were excessive and that things would change. “For at least the years of ’07, ’08 and ’09, the percentage of money from pharma has been higher than we have wanted it to be,” Mr. Fitzpatrick said.

Behind the Ivy Intifada | Compact

She also didn’t voice any objection when the term “intifada” was equated with hate speech, despite knowing well—as a native Arabic speaker born in Egypt—that the term is used broadly for mass uprisings in many contexts; it’s how the Warsaw Uprising is described in Arabic.

Association of step counts over time with the risk of chronic disease in the All of Us Research Program - PubMed

The relationship between steps per day and incident disease was inverse and linear for obesity (n = 368), sleep apnea (n = 348), gastroesophageal reflux disease (n = 432) and major depressive disorder (n = 467), with values above 8,200 daily steps associated with protection from incident disease. The relationships with incident diabetes (n = 156) and hypertension (n = 482) were nonlinear with no further risk reduction above 8,000-9,000 steps.

Primary care providers’ physical activity counseling and referral practices and barriers for cardiovascular disease prevention - PMC

Our analyses used data from DocStyles 2015, a Web-based panel survey of 1251 PCPs. Overall, 58.6% of PCPs discussed physical activity with most of their at-risk patients. Among these PCPs, the prevalence of components offered ranged from 98.5% encouraging increased physical activity to 13.9% referring to intensive behavioral counseling. Overall, only 8.1% both discussed physical activity with most at-risk patients and referred to intensive behavioral counseling. Barriers related to PCPs’ attitudes and beliefs about counseling (e.g., counseling is not effective) were significantly associated with both discussing physical activity with most at-risk patients and referring them to intensive behavioral counseling (adjusted odds ratio, 1.92; 95% confidence interval, 1.15–3.20). System-level barriers (e.g., referral services not available) were not. Just over half of PCPs discussed physical activity with most of their at-risk patients, and few both discussed physical activity and referred patients to intensive behavioral counseling. Overcoming barriers related to attitudes and beliefs about physical activity counseling could help improve low levels of counseling and referrals to intensive behavioral counseling for CVD prevention.

Social Media Use Does Not Diminish Offline Friendships in Youth - Neuroscience News

Children who spend more time using social media report spending several evenings a week with friends offline. Other studies have shown that the use of social media leads to increased closeness in friend relationships, the development of new friendships, and old friendships being reinforced. This may be a possible explanation for the findings from the Trondheim Early Secure Study.

Why is exercise good for you? Scientists are finding answers in our cells

In 2020, Snyder and his colleagues took blood samples from 36 people aged between 40 and 75 years old before, during and at various time intervals after the volunteers ran on a treadmill. The team used multiomic profiling to measure more than 17,000 molecules, more than half of which showed significant changes after exercise9. They also found that exercise triggered an elaborate ‘choreography’ of biological processes such as energy metabolism, oxidative stress and inflammation.

The search engine manipulation effect (SEME) and its possible impact on the outcomes of elections | PNAS

Specifically, we show that (i) biased search rankings can shift the voting preferences of undecided voters by 20% or more, (ii) the shift can be much higher in some demographic groups, and (iii) such rankings can be masked so that people show no awareness of the manipulation.

Social Media Fuels Eating Disorder Echo Chambers - Neuroscience News

The researchers next looked at how these communities interacted with each other. Chu described the result as “astonishing.” Clusters, or echo chambers, appeared where tens of thousands of users in the same community responded to and retweeted each other, yet they had little interaction with outside groups.

Cheers to Longevity: Couples Who Drink Together, Live Longer - Neuroscience News

Shared Drinking Habits Linked to Longevity: Couples who both drink alcohol tend to live longer compared to those with discordant drinking habits or who abstain altogether. Impact on Relationship Quality: Concordant drinking couples report higher relationship satisfaction, potentially due to increased intimacy and shared activities.

Chapel Hill Insider newsletter appears to be part of a larger network of AI-generated newsletters - Triangle Blog Blog

Some of the sites don’t have have bylines, but others do. Using LinkedIn, I looked up the authors listed on the sites that list an author. Each author runs a local digital marketing firm. So this effort could be an elaborate way to acquire lead generations, or acquire clients. But what doesn’t sit well with me is that these sites are a) not identifying their use of AI when they use AI and b) summarizing actual local journalists’ material (and taking their photos.)

Scientists' sex

A project launched in the 1960s asked school children to “draw a scientist”. By 1983, it had collected 5,000 drawings, of which only 28 depicted a female scientist. By 2018, 33% of the more than 20,000 gathered drawings, showed women. In science, too, there has been a shift towards gender equity. But serious obstacles remain, says science writer Lisa Munoz in this practical analysis, complementing it with female scientists’ vivid career stories. “No single intervention, policy, or law is enough,” she rightly notes.

Don Lemon interrogates Elon Musk on depression, his 'prescription' ketamine use and Trump in interview that got him fired from X | Daily Mail Online

'There are times when I have a negative chemical state in my brain, like depression I guess, or depression that's not linked to any negative news, and ketamine is helpful for getting one out of a negative frame of mind,' he added.  When asked if he has ever 'abused' the tranquilizing drug, Musk continued: 'I don't think so... if you use too much ketamine you can't really get work done, and I have a lot of work.'  'It's a prescription from a real doctor, not a, you know...' he added, as the conversation stalled and became awkward.  'Putting in 16-hour days, that's normal for me, and it's rare for me to even take off a weekend day, so I don't really have a situation where I can be not mentally acute for an extended period of time.

Are your earliest childhood memories still lurking in your mind—or gone forever? | Science | AAAS

Research with young rats and mice suggests they, too, can access suppressed memories with a little help. In a 2016 study, Cristina Alberini, a neuroscientist at New York University, and her colleagues gave juvenile rats a foot shock when they stepped into a dark compartment within a white box. The young animals learned to stay out of the dangerous compartment, but forgot soon after. Once the animals were older, the researchers found they could jog their memory by showing them the white box and shocking them in a different colored box. Then, when the researchers returned the rats to the original white box, the combination of the two cues made the rodents remember to stay out of its dark compartment.

Can the Ketogenic Diet Treat Mental Illness? | MedPage Today

Though 3 patients were unable to adhere to the diet for more than 14 days, the researchers concluded that following the ketogenic diet for treatment-refractory mental illness was "feasible, well-tolerated, and associated with significant and substantial improvements in depression and psychosis symptoms and multiple markers of metabolic health." More than 40% of patients experienced remission from their diagnosis, Ede said, and 64% left the hospital on less psychiatric medication than when they entered.

High-intensity Exercise Can Reverse Neurodegeneration in Parkinson’s Disease < Yale School of Medicine

Following the six-month program, brain imaging showed a significant increase in both the neuromelanin and DAT signals in the substantia nigra. This suggests that high-intensity exercise not only slowed down the neurodegenerative process, but also helped the dopaminergic system grow healthier. “Where we would have ordinarily expected to see a decline in the DAT and neuromelanin signals, we saw an increase,” says Bart de Laat, PhD, associate professor adjunct in psychiatry and the study’s first author. “We had hoped to see that the neurodegeneration would not progress as quickly or stop temporarily, but instead we saw an increase in nine out of 10 people. That was remarkable.” The study highlights the importance of including an exercise regimen as part of one’s Parkinson’s treatment plan. “The medications we have available are only for symptomatic treatment. They do not change the disease course,” says Tinaz. “But exercise seems to go one step beyond and protect the brain at the neuronal level.”

High-intensity Exercise Can Reverse Neurodegeneration in Parkinson’s Disease < Yale School of Medicine

Prior research has shown that many forms of exercise are linked to improved symptoms of Parkinson’s disease. But there has been no evidence that hitting the gym could create changes at the brain level. Now, a small proof-of-concept study involving 10 patients showed that high-intensity aerobic exercise preserved dopamine-producing neurons, the brain cells that are most vulnerable to destruction in patients with the disease. In fact, after six months of exercise, the neurons actually had grown healthier and produced stronger dopamine signals. Dopamine is a chemical that helps brain cells communicate with each other.

Should I Leave My Husband? The Lure of Divorce

To cope with the stress, I asked my psychiatrist to increase the dosage of the antidepressant I’d been on for years. Sometime around then, I started talking too fast and drinking a lot.

We finally know why live music makes us so emotional | New Scientist

The researchers found that live performances of both the negative and positive pieces consistently led to increased brain activity in the left amygdala – the region of the brain that is strongly linked to assigning sensory stimuli, such as sounds, to certain emotions.

'Eye Opening': Chatbot Outperforms Ophthalmologists | MedPage Today

The ChatGPT chatbot powered by GPT-4 scored better than the panelists on measures of diagnostic and treatment accuracy when it analyzed 20 real-life cases and considered 20 possible patient questions, reported Andy S. Huang, MD, of the Icahn School of Medicine at Mount Sinai in New York City, and colleagues in JAMA Ophthalmology opens in a new tab or window .

Cortical signatures of sleep are altered following effective deep brain stimulation for depression | Translational Psychiatry

eep brain stimulation (DBS) of the subcallosal cingulate cortex (SCC) is an experimental therapy for treatment-resistant depression (TRD). Chronic SCC DBS leads to long-term changes in the electrophysiological dynamics measured from local field potential (LFP) during wakefulness, but it is unclear how it impacts sleep-related brain activity. This is a crucial gap in knowledge, given the link between depression and sleep disturbances, and an emerging interest in the interaction between DBS, sleep, and circadian rhythms. We therefore sought to characterize changes in electrophysiological markers of sleep associated with DBS treatment for depression. We analyzed key electrophysiological signatures of sleep—slow-wave activity (SWA, 0.5–4.5 Hz) and sleep spindles—in LFPs recorded from the SCC of 9 patients who responded to DBS for TRD. This allowed us to compare the electrophysiological changes before and after 24 weeks of therapeutically effective SCC DBS. SWA power was highly correlated between hemispheres, consistent with a global sleep state. Furthermore, SWA occurred earlier in the night after chronic DBS and had a more prominent peak. While we found no evidence for changes to slow-wave power or stability, we found an increase in the density of sleep spindles.

'Revelatory' study finds a smoking impact that remains after quitting

People who smoked had increased inflammatory responses, but those higher levels were transient, dropping after smoking cessation. But the effects on the adaptive response persisted for many years after quitting, changing the levels of cytokines released after infection or other immune challenges.

Still Fab

Carroll James wasn't a rock DJ, and his audience was mostly grown-ups. James did a talky afternoon drive-time show for WWDC, a popular AM station. Back then, WWDC was a laid-back outlet with a so-called "middle of the road," or MOR, format that was aimed at an older audience. What did it do besides break the Beatles? When it wasn't running its oddball contests, the station drew on a mostly pop play list, mixing Andy Williams and Al Hirt with soft-rock acts like Ruby and the Romantics, Bobby Vinton, and Ben E. King. WWDC's morning guy had been around for decades, played the organ behind his own wake-up patter, and had a pair of miked, twittering canaries in the studio with him. At night, WWDC didn't play any music at all; it interviewed touring book authors. The only show it aimed at a young audience was in the evening, when its preferred adult listeners were watching TV, and that show was targeted at the dutiful children of the station's core middle-class following. The "teen" show was called The House of Homework, and its gimmick was letting kids call in to ask for help with their assignments. In short, WWDC was a station for dorks.

A local tip helps reveal an ancient ‘arcade’ in Kenya’s highlands | YaleNews

“Modern people in the region tend to play games like Mancala when they are out herding,” she said. “That’s probably what they were doing here. People tend to look at early life as brutish, nasty, and short. But perhaps life was not all about survival.”

Amid $1 billion Medicaid shortfall, Indiana cuts aid to aged and disabled

Davis hasn't had a job in 15 years because taking care of her son is a full-time occupation. The Davises have been approved for nursing hours since 2016 but have never been able to find a nurse to hire. In 2018 Anastasia Davis learned of the program that would pay her for her caregiving, but she was unable to enroll until 2022. The financial strain of caregiving without income sent the family into debt, she said.

Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review - PubMed

Fifteen studies (8 involving coffee and 7 caffeine) were included. Increased adiponectin levels were found in four of seven trials comparing filtered coffee/caffeinated coffee with placebo or comparing its levels at baseline and after consumption of medium or dark roasted coffee, but no change was seen in caffeine trials. None of the five studies assessing the effects of coffee found changes in C-reactive protein (CPR), but one out of three trials found decreased CPR levels in response to caffeine. Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies. Caffeine increased IL-10 levels in two of three trials. These data suggest a predominant anti-inflammatory action of coffee but not of caffeine consumption. Moreover, the proinflammatory and anti-inflammatory responses to caffeine point to its complex effects on the inflammatory response.