henry copeland @hc

having fun with people and pixels, via racery, pullquote, twiangulate, improv, running

Recent quotes:

A Battle for the Soul of Marfa – Texas Monthly

He is oblivious in the way of people accustomed to being fussed over. (“I think we’re the largest employers of Marfa High School kids,” Crowley says, noting that the locals he employs are often “surprised to learn there are different types of wine than white and red.” Still, they’re a steady source of labor, as few have the opportunity to leave home. “They aren’t going anywhere.”)

How to Make Your Strength Routine Evidence-Based | Outside Online

Put all these results together, shake them around, and you emerge with some fairly simple guidelines for people who want to get stronger but aren’t planning to enter any bodybuilding competitions. Pick a range of exercises covering the body’s major muscle groups (here’s a good place to start, courtesy of Brad Stulberg). Do at least one set of each, several times a week, aiming for about 8 to 12 reps, and be consistent about your routine. If you use lighter weights, push close to failure on each set. To maximize size gains, do more sets.

Texas Psychiatrist Karen Wagner Under Scrutiny - AHRPAHRP

co-authored the notorious, ghostwritten Paxil pediatric study #329, whose lead author, Martin Keller, MD, was replaced last month as chairman of psychiatry at Brown University. The Glaxo-paid authors of study #329 helped the company promote the myth that Paxil was "safe and effective" for use in children as early as 1998: in a poster presentation, Dr. Wagner claimed "The results of this study demonstrate the safety ofparoxetine in the treatment of adolescent depression. Side effects were modest with paroxetine." [2]  But internal Glaxo emails show the data from pediatric Paxil trials were negative.

Political Hobbyists Are Ruining Politics - The Atlantic

In the United States, political habits vary significantly by race and education. In a 2018 survey,[…]white people reported spending more time reading, talking, and thinking about politics than black people and Latinos did, but black people and Latinos were twice as likely as white respondents to say that at least some of the time they dedicate to politics is spent volunteering in organizations. Likewise, those who were college-educated reported that they spend more time on politics than other Americans do—but less than 2 percent of that time involves volunteering in political organizations. The rest is spent mostly on news consumption (41 percent of the time), discussion and debate (26 percent), and contemplating politics alone (21 percent). Ten percent of the time is unclassifiable.

Your Life is Driven by Network Effects

Compatibility between two people in terms of their individual characteristics is sometimes much less important than the compatibility between their networks. This is one possible reason why there is a surprisingly low divorce rate amongst arranged matches made solely on the basis of compatibility between kin networks.

Your Life is Driven by Network Effects

In short, the networks of human connections in your life create a force that guides you down a path not always fully of your intention, through the mechanism of 100s of small interactions.  Further, this “network force” compounds over time. The longer your relationships, cliques, and communities persist, the more they shape your destiny.

Trends in annual ambulatory prescribing of Schedule IV benzodiazepines,... | Download Scientific Diagram

Trends in annual ambulatory prescribing of Schedule IV benzodiazepines, Schedule II opioids, or both, United States. Number of annual visits among each medication group, 1993-2014; all analyses were conducted using survey-design elements for visit or physician weight, clustering, and stratification to yield national inferences.
The president reportedly called Afghanistan a “loser war,” and told his military leaders: “You’re all losers... You don’t know how to win anymore... I want to win... We don’t win any wars anymore... We spend $7 trillion, everybody else got the oil and we’re not winning anymore.” It’s reported that Trump was so angry at this point that he wasn’t breathing properly. […]In his most incendiary comment, Trump—a man who, remember, managed to get out of military duty in Vietnam due to a supposed bone-spur problem—is said to have told the assembled forces: “I wouldn’t go to war with you people... You’re a bunch of dopes and babies.”

Harnessing wearable device data to improve state-level real-time surveillance of influenza-like illness in the USA: a population-based study - The Lancet Digital Health

Our mchange models were better at predicting change with a 1-week lag compared with a 1-week lead. It is possible that an ILI infection results in an elevated RHR for several weeks after initial infection. Previous studies have also indicated that an elevated heart rate can occur before symptom onset.16 Since influenza has an incubation period of 1–4 days, there is only a short opportunity to identify infections before symptom onset. However, since individuals with febrile respiratory illness typically seek care 3–8 days after symptom onset,18 it is conceivable that ILI cases could be identified via sensor data earlier than through traditional, clinic-based ILI surveillance. Early identification via our method might be more likely if rates were predicted at a daily, rather than weekly, rate.

Harnessing wearable device data to improve state-level real-time surveillance of influenza-like illness in the USA: a population-based study - The Lancet Digital Health

The impact of infections on an individual's RHR has been documented in several studies. One study found ill participants had RHRs that were elevated by 2·02–4·66 SD above their normal measurements.16 A study that examined 27 young men with acute febrile infections found that heart rates increased by 8·5 bpm per every 1°C increase in temperature.11 Similarly, a study among children with acute infections found that heart rate rose by 9·9–14·1 bpm for every 1°C increase in temperature, with higher increases in younger children.17 These studies indicate that infections can increase heart rate, probably due to increased body temperature and inflammatory responses as the body fights off an infection.

Health care data-sharing rules touch off intense lobbying fight - POLITICO

But many in the industry say they have patients’ best interests at heart in asking for increased privacy protections as part of the rule. “The primary beneficiaries of this rule are venture capitalists and others taking advantage of patient data,” said Epic executive Sumit Rana in an interview Monday. Disclosing patient records in unfettered fashion can hurt patients, he said. The rule’s promise of eased access to a patient’s entire medical record through an interface is an invitation for app developers — well-funded and sketchy alike — to pick over patient data and commercialize it, he said. In that, he said the proposed rules “go well beyond the 21st Century Cures Act,” which sought to modernize health care with better use of IT.

Verily tangos with a health tech partner — and steps on a few toes - STAT

In his presentation, Conrad described tremendous potential for its work with Dexcom to help patients connect factors like diet and exercise with their blood sugar levels. And he showed an image of the new device, which is smaller than a quarter and called the G7. Conrad also announced — for the first time — that the device contained an accelerometer, so patients could see in real time how exercise impacted their disease. The Dexcom CEO said he was not pleased about Conrad’s decision to share the image or to announce the accelerometer. He didn’t want competitors to know about either detail, he said. More importantly, he isn’t certain the accelerometer will make it into the version of the device slated to launch at year’s end, he added. “That is a competitive thing that I actually did not want disclosed,” said Sayer, who is known as a straight shooter. “I’d rather that not even be public. We haven’t told anybody and we weren’t planning to.”

The medium is the medicine: a novel history

Medicine’s history is often presented as a long sequence of discoveries, all made in laboratories. In fact, though, the biggest changes in US medicine over the last 200 years were propelled by forces beyond medicine, specifically, in media. How medicine’s stakeholders communicated in different eras ⁠— in formats including medicine shows, newspapers, cars, telephones, medical journals, and TVs ⁠— determined what, and how much, was communicated. Where information flows, medicine follows: now social media, biomonitors, and machine learning are ushering in a new age, one of patient-generated medicine.

The role of social media in cardiology - ScienceDirect

Social media may offer a way to distinguish and disseminate medical information much more rapidly. A few examples show the speed with which digital media can influence patient care.

FDA and NIH let clinical trial sponsors keep results secret and break the law | Science | AAAS

The University of Texas MD Anderson Cancer Center and the Mayo Clinic both failed to report results on time, or at all, in about two-thirds of their trials. Yale University failed to do so in 84% of its trials. NIH’s own institutes also had a bad record. They are directly responsible for reporting results when they sponsor studies done by agency staff or some grantees, and the top four NIH institute sponsors, taken together, reported results late or not at all in more than six of every 10 trials Science looked at. Contacted for comment, none of the institutions disputed the findings of this investigation. In all 4768 trials Science checked, sponsors violated the reporting law more than 55% of the time. And in hundreds of cases where the sponsors got credit for reporting trial results, they have yet to be publicly posted because of quality lapses flagged by ClinicalTrials.gov staff (see sidebar).

Scientists bring personalized medicine to the biology of aging - STAT

“Of course the whole body ages,” said biologist Michael Snyder, who led the study. “But in a given individual, some systems age faster or slower than others. One person is a cardio-ager, another is a metabolic ager, another is an immune ager,” as shown by changes over time in nearly 100 key molecules that play a role in those systems. “There is quite a bit of difference in how individuals experience aging on a molecular level.” Crucially, the molecular markers of aging do not necessarily cause clinical symptoms. The study’s “immune” agers had no immune dysfunction; “liver agers” did not have liver disease. Everyone was basically healthy. If aging is truly personal, understanding an individual’s ageotype could lead to individualized, targeted intervention. “We think [ageotypes] can show what’s going off track the most so you can focus on that if you want to affect your aging,” Snyder said.

In mice, alcohol dependence results in brain-wide remodeling of functional architecture -- ScienceDaily

"The neuroscience of addiction has made tremendous progress, but the focus has always been on a limited number of brain circuits and neurotransmitters, primarily dopaminergic neurons, the amygdala and the prefrontal cortex," said senior author Olivier George, PhD, associate professor in the Department of Psychiatry at UC San Diego School of Medicine. "Research groups have been fighting for years about whether 'their' brain circuit is the key to addiction. Our results confirm these regions are important, but the fact that we see such a massive remodeling of the functional brain architecture was a real shock. It's like studying the solar system and then discovering that there is an entire universe behind it. It shows that if you really want to understand the neurobiological mechanisms leading to addiction, you can't just look at a handful of brain regions, you need to look at the entire brain, you need to take a step back and consider the whole organ." George said the findings further undermine the idea that addiction is simply a psychological condition or consequence of lifestyle. "You would be surprised at how prevalent this view remains," he said. "The brain-wide remodeling of the functional architecture observed here is not 'normal.' It is not observed in a naïve animal. It is not observed in an animal that drinks recreationally. It is only observed in animals with a history of alcohol dependence and it is massive. Such a decrease in brain modularity has been observed in numerous brain disorders, including Alzheimer's disease, traumatic brain injury and seizure disorders." Brain modularity is the theory that there are functionally specialized regions in the brain responsible for different, specific cognitive processes. For example, the frontal lobes of the human brain are involved in executive functions, such as reasoning and planning, while the fusiform face area located in the lower rear of the brain is involved in recognizing faces. Reduced modularity, said George, likely interferes with "normal neuronal activity and information processing and contributes to cognitive impairment, emotional distress and intense craving observed in mice during abstinence from alcohol." Due to the format of the testing, George said it was not clear if the reduced modularity was permanent. "So far, we only know that it lasts at least one week into abstinence. We have not tested longer durations of abstinence, but it's one of our goals."

Britain secretly funded Reuters in 1960s and 1970s - documents - Reuters

The secret government financing of Reuters - as set out in the documents - amounted to 245,000 pounds ($317,838 at current exchange rates) per year before 1969 but then reduced to 100,000 pounds per year in 1969-1970 and nothing in 1972-1973. “The new relationship established with Reuters in the Middle East and Latin America can lead to valuable goodwill and cooperation with the Agency on a global scale,” John Peck, former head of the IRD, said in the documents.
Seven years after Pullquote launched, there’s STILL nothing out there that performs its handy functions so simply. So we’ve been fixing bugs, upgrading hardware, and updating the code powering Pullquote’s Chrome extension. The original functionality remains free: quickly tweet a quote—with a swipe and two clicks—rather than flipping back and forth between tabs, paraphrasing text and copy/pasting a URL⁠. As a bonus, extension users can immediately locate a quote on a long page. We apologize for neglecting Pullquote while building AdBiblio, Racery, and WhichWorksBest. They’re all solid and earning money. To ensure Pullquote is also supported going forward, we’re adding a Pullquote Pro package with extra features for power users. These extra features ($40/year or $4/month) include: Pullquoting from multiple Twitter accounts, scheduling a tweet, shortening a Pullquote and adjusting its font or color, filing and indexing quotes, and⁠—our most requested feature⁠—quickly Pullquoting to Facebook!  Again, you’re welcome to use Pullquote’s core “tweet a quote” functionality for free.
We apologize for neglecting Pullquote. To ensure Pullquote gets supported going forward, we’re adding a Pro package with extra features for power users. These extra features ($40/year or $4/month) include: Pullquoting from multiple Twitter accounts, scheduling a tweet, shortening a Pullquote or adjusting its font or color, filing and indexing quotes, and⁠—the feature most requested by past users⁠—quickly pushing a Pullquote to Facebook!

Baby and adult brains 'sync up' during play: It's not your imagination -- you and your baby really are on the same wavelength -- ScienceDaily

When they looked at the data, the researchers found that during the face-to-face sessions, the babies' brains were synchronized with the adult's brain in several areas known to be involved in high-level understanding of the world -- perhaps helping the children decode the overall meaning of a story or analyze the motives of the adult reading to them. When the adult and infant were turned away from each other and engaging with other people, the coupling between them disappeared. That fit with researchers' expectations, but the data also had surprises in store. For example, the strongest coupling occurred in the prefrontal cortex, which is involved in learning, planning and executive functioning and was previously thought to be quite underdeveloped during infancy. "We were also surprised to find that the infant brain was often 'leading' the adult brain by a few seconds, suggesting that babies do not just passively receive input but may guide adults toward the next thing they're going to focus on: which toy to pick up, which words to say," said Lew-Williams, who is a co-director of the Princeton Baby Lab.
The original functionality remains free: quickly tweet a full quote—with a swipe and two clicks—rather than flipping back and forth between tabs to paraphrase text and then copy/paste a URL⁠. As a bonus, extension users can immediately locate a quote on a long page. To support Pullquote going forward, we’ve added a Pro package, which includes  features for power users: Pullquoting from multiple Twitter accounts, scheduling a tweet, trimming a Pullquote or adjusting its font or color, filing and indexing quotes, and⁠—the feature most requested by past users⁠—quickly pushing a Pullquote to Facebook!
But cooling job creation is to be expected in the 11th year of an economic expansion, and as the government’s report, released Friday, showed, the slowdown has been gradual. There were weak spots. Revisions for the previous two months reduced last year’s total gains by 14,000 jobs. And the struggling manufacturing sector lost 12,000 positions in December. The average monthly gains for the last three months of the year were 184,000, on par with the rest of the year.
But cooling job creation is to be expected in the 11th year of an economic expansion, and as the government’s report, released Friday, showed, the slowdown has been gradual. There were weak spots. Revisions for the previous two months reduced last year’s total gains by 14,000 jobs. And the struggling manufacturing sector lost 12,000 positions in December. The average monthly gains for the last three months of the year were 184,000, on par with the rest of the year. For the full year, the economy added 2.1 million jobs, fewer than the 2.7 million created in 2018, but more than enough to handily outpace population growth. It is the smallest annual increase since 2011.
But cooling job creation is to be expected in the 11th year of an economic expansion, and as the government’s report, released Friday, showed, the slowdown has been gradual. There were weak spots. Revisions for the previous two months reduced last year’s total gains by 14,000 jobs. And the struggling manufacturing sector lost 12,000 positions in December. The average monthly gains for the last three months of the year were 184,000, on par with the rest of the year. For the full year, the economy added 2.1 million jobs, fewer than the 2.7 million created in 2018, but more than enough to handily outpace population growth. It is the smallest annual increase since 2011. “I think 2019 was a year of consolidation,” Mr. Daco said. “We had relatively strong and steady job growth over the year despite a number of headwinds including a trade war with China, weaker global activity and heightened policy uncertainty.”
Sleep has been conceptualized as “activity-dependent”, hence a response to prior waking experience, and proposed to be “the price the brain pays for plasticity during wakefulness”. We here propose that at the level of neuronal networks, particularly those arising from isolated embryonic thalamocortical cells maintained in culture, it represents a default mode of functioning. We show that cell assemblies in ex vivo cultures express powerful sleep specific patterns of oscillatory activity, as well as metabolic and molecular signatures of the sleep state. We summarize recent evidences that support our hypothesis and discuss potential applications of developing ex vivo sleep models to answer open questions in the field.