Pullquote: @hc

Recent quotes:

Can the US Dodge a Recession? This Economist Thinks So - Bloomberg

“In science we use models all the time, and they’re simplifications of reality,” he said. “And part of the skill of the scientist is to know when to deploy the model and when not to or, in other words, to know the limitations of the model. And maybe I’m in a good position of knowing the limitations, given that it’s my model.”

#prediction #interst-rates #duke - bloomberg.com

Statistical considerations for rare diseases drug development. - PubMed - NCBI

One of the most challenges for rare disease clinical trials is probably the availability of a small patient population. It is then a great concern on how to conduct clinical trials with a small number of subjects available for obtaining substantial evidence regarding safety and effectiveness for approval of the rare disease drug product under investigation. FDA, however, does not have the intention to create a statutory standard for approval of orphan drugs that are different from the standard for approval of drugs in common conditions. Thus, it is suggested that innovative trial designs such as a complete n-of-1 trial design or an adaptive design should be used for an accurate and reliable assessment of rare disease drug products under investigation. In this article, basic considerations, innovative trial designs, and statistical methods for data analysis are discussed. In addition, some innovative thinking for the evaluation of rare disease drug products is proposed.

#n-of-1 #duke - ncbi.nlm.nih.gov

Get an email when henry copeland finds good
quotes on these topics:

All

depression x208 keto x6 paleopsychiatry x68 exercise x173 medicalindustrialcomplex x282 psychiatry x56 coronavirus x88 long-covid x1 metformin x2 nocebo x2 placebo x36 n-of-1 x24 self-experimentation x1 cities x27 paris x6 poetry x18 schizophrenia x20 dopamine x48 grief x3 learning x30 brain x157 fMRI x33 music x80 synchronize x202 focus x21 mind-body x17 mindfulness x10 goog x24 SEO x4 diffusion x1 twiangulate x6 racery x85 virtual x12 postpandemic x2 hrv x14 sleep x89 investing x16 keynes x1 adbiblio x7 AI x42 journalism x57 jobs x17 markets x21 overextrapolation x1 stocks x2 vaccines x7 email x9 writing x64 california x9 food x88 inflation x11 duke x2 interst-rates x3 prediction x107 Hungary x81 orban x7 ALS x1 microbiome x72 statins x7 community x57 love x18 psychology x107 adderall x1 ADHD x72 collusion x1 housing x3 advertising x86 musk x1 origin-story x6 start-ups x58 fiction x5 improv x17 magic x7 homeshoring x1 investment x1 repression x1 health x203 twins x1 debt x2 civil-war x2 epigenetics x27 racism x31 socializing x15 artifacts x2 culture x10 europe x46 optimism x2 self-image x20 oximeter x3 wearables x33 contagion x7 facebook x47 masks x1 hysteria x1 nytimes x43 populism x2 cancer x35 Russia x38 Ukraine x7 marriage x49 memory x103 ripples x2 meditation x48 pain x24 blogads x19 nanoniche x5 self-publishing x27 substack x1 Twitter x26 economics x35 trump x59 USAUSA x116 democracy x7 bullshit x1 carlson x2 soros x2 authoritarianism x1 woke x2 friends x27 nose x4 art x49 autobiography x2 academia x70 education x47 history x89 politics x66 comedy x13 movies x14 social-media x58 alcohol x46 1491 x1 clovis x1 eyes x12 deconstruction x9 Yale x25 sleep-apnea x7 goals x12 managing x245 greenbrier x59 advice x2 knowledge-workers x9 secretword x1 collaboration x36 diversity x8 teams x5 hiring x1 practice x7 talent x1 nationalism x7 metabolism x12 hte x21 science-is-dead x3 prefrontal-cortex x8 rtms x1 hyperbole x4 mediumismedicine x36 propofil x1 concussion x1 TBI x6 heart x31 connectome x36 creativity x40 running x94 vision x22 flocks x1 hive-mind x11 murmuration x1 circadian x84 diabetes x77 time-restricted-eating x6 bluelight x7 resting-heart-rate x7 narratives x116 Dont-use-mouthwash-after-running x2 weightlifting x5 peanuts x2 sunlight x69 vitamin-d x5 breath x8 central-europe x23 neanderthals x2 trust x11 sunk-costs x2 children x20 immune-system x35 Alzheimers x26 neurons x109 hsp90 x1 bonds x8 wall-street x18 antidepressants x28 overdiagnosis x2 withdrawal x5 second-order-effects x1 unintended-consequences x4 censorship x7 lobbying x4 science-worship x1 pharma x63 inequality x54 micro-biome x17 insulin x22 melatonin x6 conversation x24 coupling x3 relationship x3 engram x3 allergy x19 risk x12 dementia x2 inflamation x54 evolution x16 panpsychist x5 synapses x12 aging x71 crypto x4 t-cells x10 KOL x1 confidence x6 medicine x44 pricing x28 valuation x1 workation x1 presence x2 wisdom x5 anxiety x56 publishing x95 gut x14 czechoslovakia x2 vaculik x2 tau x1 foucault x1 government x2 fasting x9 longevity x5 distraction x5 blood-thinners x1 pulmonary-embolism x18 group-think x7 vitamin-b-12 x1 myelin x5 UV x10 darwin x3 intellectual-history x2 histamine x3 serotonin x20 cognitive-bias x4 heuristic x1 havel x8 rfe x1 vitamin-k x1 bogus-studies x8 FDA x17 language x49 maps x40 words x37 divorce x5 fat x19 muscles x11 influence x6 networks x68 prague x1 truth x1 deprescribing x1 polypharma x4 precision-medicine x1 gamification x1 cholesterol x3 obesity x8 EKG x3 immortality x10 perception x6 meaning x6 purpose x3 cortisol x12 dogs x9 concussions x19 bass x6 ohio x4 emotion x17 VC x19 digiceuticals x53 cerebral-cortex x4 consciousness x33 thalamus x2 addiction x85 luck x4 meritocracy x5 wealth x6 mimicry x1 nicotinamide x1 complexity x18 modernity x11 zoom x2 hiit x5 elites x1 college x10 HDL x1 liver x2 leadership x10 sexism x50 reviews x8 commuting x5 innovation x132 hypnosis x4 normal x1 voice x15 nutrition x3 disruption x25 software x15 bayes x1 statistics x7 local x11 newspapers x28 idioms x1 moderna x1 boredom x2 dreams x10 happiness x25 carbs x13 mice x8 competition x5 peers x17 models x6 simulation x1 mushrooms x1 psychotropics x3 fractals x7 power-law x2 glia x5 antibiotics x11 free-speech x1 fear x10 DNA x77 methylation x3 density x1 projection x2 italy x7 search x2 doctors x41 paleotherapy x123 flexibility x2 spotify x1 wfh x2 dhc x1 texas x1 IQ x21 gwas x2 naps x5 acentricity x2 race x44 capital-riot x1 work x11 moon x3 qanon x11 paranoia x9 psychosis x54 death x26 Los-Angeles x3 mobile x36 archeology x6 arrowheads x1 center-vs-edges x1 gamestop x1 rationality x5 knee x1 twitches x1 metaphors x23 communism x17 status x5 more-moore x18 predictions x21 abstraction x11 animals x11 money x13 media x35 anti-semitism x8 mentoring x2 sex x4 mood x22 bipolar x11 lithium x8 apixaban x2 brown-fat x1 france x29 bitcoin x6 movement x3 fitbit x25 churchill x1 bias x19 bio-sensors x4 wearable x7 nature x22 biocentrism x2 bots x11 China x9 library x4 randomness x7 dogma x2 novelty x3 rhythm x11 waves x10 motivation x38 zen x5 meat x3 tinnitus x7 agency x8 amygdala x15 neurotypes x2 religion x26 conspiracies x17 puzzle x5 slack x2 clinical-trials x5 nyc x46 plasticity x24 lean x2 architecture x10 home x14 cancel-culture x2 oxytocin x3 apps x28 tracking x3 privacy x14 privilege x2 stimulants x47 subjectivity x7 TV x10 blogs x37 machine-learning x4 epidemiology x1 black-swans x4 ecosystems x1 poker x2 conflict-of-interest x3 23andme x19 Gpld1 x1 CBT x20 robots x12 theranostics x17 research x5 albumin x1 blockchain x1 chemical-imbalance x2 taleb x1 telemedicine x3 law x14 railroads x1 witch-hunts x1 taxes x9 class x11 game-theory x1 armageddon x27 police x15 genius x1 strength x5 parkinsons x5 solitude x3 bubble x4 econ x59 bankruptcy x1 end-times x10 booksellers x7 podcasting x5 whichworksbest x8 hippocampus x39 viral x11 photography x5 fakes x3 glucose x8 probability x2 hospitals x3 dosage x2 middleages x2 kidney x2 salt x3 North-Carolina x32 Israel x6 blood-pressure x11 IgE x1 productivity x8 clusters x1 billionaires x1 2020 x1 spam x2 cleveland x1 success x7 c-diff x1 cherrypicking x1 methionine x1 england x12 payola x5 LCHF x1 budapest x5 40-Hz x2 demographics x5 midwest x5 immigration x5 design x33 print x5 tribalism x1 ehr x5 orphan-diseases x1 marfa x1 benzos x9 epic x1 dexcom x1 NIH x1 RCTs x8 cold-war x1 spying x3 USSR x35 games x30 parenting x22 bones x1 quantified-self x6 empathy x13 Great-to-do-business-with-you x1 contrarian x5 science x25 trial-and-error x7 ecg x1 vegan x2 bun x1 nicotine x8 cognition x16 malpractice x18 mucus x1 McLuhan x3 uber x1 unemployment x1 bmj x1 cars x12 sixties x1 block-that-metaphor x8 criticality x2 amazon x53 billing x1 bdnf x8 asthma x1 open-source x5 out-of-network x1 big-data x40 p-value x1 silent-sam x2 the-south x11 DIY x6 growth x5 mirror-neurons x7 apnea x6 infection x11 fiber x3 cvs x1 health-apps x6 generics x2 tolerance x1 caffeine x7 glutamate x6 prozac x2 smart-api x1 busted-medicine x1 insurance x7 alexa x4 hope x1 metrics x1 fossil x3 poverty x13 docbots x16 RIP x33 fail x19 confounding x6 weird x1 diagnostics x7 wwb x12 teens x11 lateral-septum x1 snapshots x1 heat x3 SSRI x17 dronabinal x2 chronic x1 gluten x2 CSA x1 calories x7 chess x4 dendrites x3 uniqueness x1 deterministic x1 omnigenics x1 clothing x6 stress x32 misdiagnosis x6 beatles x5 turicibactor x1 loneliness x6 time x29 paradigm-shift x2 organoids x1 pollution x4 experiments x6 theory x20 gambling x7 christakis x5 UX x9 iga x2 marketing x48 social-shopping x6 nano-health x2 weightloss x15 anti-enlightenment x12 confirmation-bias x3 cbd x3 adventure x5 compsci x4 nasa x2 gamma-oscillations x4 dunning-kruger x6 mrsa x1 open-science x2 noise x4 homeostasis x3 REM x7 fitness x16 straw-horses x1 dentate-gyrus x1 neurogenesis x1 qs x2 thurston-howell-iii x1 hertz x2 joy x2 sales x17 telomeres x7 eeg x5

literature x21 whole-grain x1 ending x3 hindsight x2 agnotology x1 epistemology x1 fragmentation x3 uniforms x1 schema x4 polygenic x1 hand-written x3 walking x19 wellness x3 bio x4 aspirin x4 crp x1 dtc-health x1 simplify x9 life x49 dentists x2 vicious-circle x6 injury x6 shoes x4 sods-law x1 relapse x1 auctions x1 recession x2 biofeedback x2 corpus-callosum x1 global-warming x3 here-we-go-again x1 cingulate-cortex x3 autism x3 garlic x1 jokes x24 laughter x3 dtc-gt x3 instagram x3 deep-brain-stimulation x5 biomarkers x2 lab-on-a-chip x2 apple x29 pressflex x1 pathways x1 omega-3 x1 vr x27 family x12 DMT x1 square-peg x1 blame x5 gadgets x3 neighbor-effects x2 PTSD x11 mitochondria x6 autophagy x1 exponential x1 MBA x4 yeast x1 health-care-desert x1 training x12 addi x1 ritalin x2 life-logging x9 prisoners-dilemma x2 free-radicals x1 hypothalmus x3 belief x3 radio x4 reality x2 citizen-medicine x1 health-coach x2 Renaissance x4 GABA x7 causality x9 vagus x8 pot x18 big-bro x3 lyme x3 bell-curve x1 510k x1 body-language x9 capitalism x3 caudate-nucleus x2 phrenology x1 covington x1 press x12 hipaa x1 MAGA x1 xarelto x2 all-of-us x1 phosphate x1 dsm x6 netflix x2 touch x5 left-handed x2 analytics x6 categories x2 mission-creep x1 subconscious x2 india x1 identity x8 avoidance x3 denial x1 cannabinoids x5 pans x5 lateral-orbitofrontal-cortex x1 symphony-not-soup x1 chapel-hill x1 anger x3 loving-kindness x2 altitude x1 lungs x1 oxygen x1 innovators-dilema x17 testosterone x1 default-network x1 avant-garde x1 Optimization x4 grandcanyon x1 hiking x1 self-fulfilling-prophecy x1 theta x1 libertarians x5 welch x1 COMT x2 avatars x2 CTE x3 cult x4 generalizations x1 glutamine x1 nudges x1 ethics x1 cerebellum x7 psilocybin x4 hematology x1 wine x5 astrocytes x1 Chrdl1 x1 pop-ups x1 putin x4 panic-attacks x1 right-vagal-nerve x1 caring x2 HPA x2 lawyers x3 loss x7 suicide x6 9-11 x2 naltrexone x1 aristocracy x2 lenin x2 Marx x6 new-york x8 vietnam x3 gratitude x5 vacation x1 cycling x16 fgf21 x1 war-on-drugs x8 civil-rights x9 statues x1 banking x1 london x11 zero-sum x1 green x3 trees x5 extinction x3 smoking x10 breakfast x1 glycogen x1 trf x3 prosthetics x1 pessimism x1 leaderboards x3 nitric-oxide x1 customers x8 cytokines x6 travel x4 arthritis x3 barefoot x8 sports x16 judaism x3 names x6 ego x6 yoga x3 ketamine x1 adenosine x1 siblings x1 CNS x1 macrophages x1 kindle x1 SXSW x4 yes-and x1 GOP x15 wiring x1 DBS x4 strategy x11 chronotherapy x3 pr x2 reading x29 clock x1 positivism x1 scale x3 tunable-leds x1 forgiveness x2 tablets x3 AACAP x1 listening x5 acupuncture x1 reddit x5 order x4 tb x1 noradrenline x1 crime x1 harvard x11 speakersbureaus x4 trauma x1 biederman x5 courage x2 enlightenment x6 gyrification x1 lilly x1 chocolate x1 DHEA x1 jetlag x2 NIMH x1 LTP x1 mono x1 encephalitis x1 NMDA x1 ambiguity x1 peripheral x5 pivot x2 style-substance x1 web x9 shooters x1 headaches x2 circular-reasoning x1 stem x1 anti-oxidents x1 malls x1 retailing x1 totalitarian x1 heller x1 subliminal x2 tools x15 dance x3 parallax x1 programmatic x12 branded-content x2 subscription x6 temperature x1 multiple-sclerosis x2 KGB x4 quacks x1 centaur x2 gould x1 frats x3 fog x1 syndrome x3 floating x1 swimming x3 platforms x4 fashion x10 jazz x1 cognitive-dissonance x1 stairs x3 compromise x4 energy x8 native-advertising x11 flow x1 salad x1 3d x4 orbit x2 space x6 rumination x3 neurofeedback x1 famous-last-words x3 metacognition x1 moscow x1 automation x7 autonomy x4 grammar x4 smile x2 gawker x45 gossip x6 weather x2 d4 x1 Hollywood x25 real-estate x18 stalin x1 profanity x1 compound-interest x2 Freud x3 editing x6 video x3 ultra x8 Enterprise-Funds x1 PH x1 beer x5 hops x2 blog x6 medicaid x1 suburbia x5 Hemingway x3 annotation x9 malware x1 CAMP x1 hypertension x1 tuberculosis x1 sad x4 thyroid x1 online-medicine x1 hypocracy x3 feedback x6 shibboleths x7 coaching x2 GAO x1 framingham x1 mantras x4 GIFs x3 marathon x3 bookstores x8 preventive-medicine x1 FOXO3 x1 sauna x2 LOL x35 offices x3 rubegoldberg x3 whiteboards x3 GLO1 x1 ACL x3 impact x1 vitamins x3 alienation x3 cms x8 Wapo x8 limbic x1 Pills-no-better-than-pushups x1 daily x1 Bannon x2 arbitrage x4 guilt x1 OCD x2 impulse x2 19thcentury x1 quick-fixes x1 ACA x2 chance x1 destiny x2 expats x1 biography x9 labor x4 cloud x2 benchmarks x3 crowdsourcing x8 obama x2 calendar x4 mormon x1 elephants x1 tea-party x6 irony x13 nostalgia x5 charity x8 millennials x2 rhetoric x18 UWS x1 resilience x1 pullquote x21 dichotomy x1 VO2 x1 acting x5 quality-of-life x1 paradox x6 clinton x4 secrecy x8 trends x3 sarick x1 pride x3 Bach x2 theater x4 endorphins x1 rosemary x1 logistics x1 islam x1 golf x1 adrenaline x1 npr x1 SCOTUS x5 rules x1 linked-in x1 desegregation x6 audiences x3 mindreading x20 diffabilities x2 chickens x1 biz-models x16 discovery x6 serendipity x19 dolphins x2 ocean x2 migration x2 walmart x2 commodification x4 hypocrisy x8 yahoo x8 globalization x1 etiquette x2 anonymous x3 2016 x1 vectors x1 transparency x3 MIT x1 meta x16 gluts x6 tononi x2 curation x5 colorado x1 WTF x2 guns x3 boondoggle x3 greenwald x2 Obit x4 tech x11 venn-diagram x1 stockholm-syndrom x3 carr x14 counter-intuitive x3 earthquakes x3 facts x1 silicon-valley x12 nixon x1 nyt x3 infographics x2 trolls x2 water x5 south x2 runwme x3 memes x2 GLBT x2 tesla x1 racewithme x12 sanity x3 runwithme x16 non-sequitors x1 Klan x1 Canada x1 drought x1 rationing x1 hacks x2 samizdat x2 book-tours x3 nicknotned x1 SUXORZ x7 fact-checking x2 ncaa x1 run-wither x1 newsletters x3 mlk x1 rfk x1 viewability x1 api x1 crowd-sourcing x1 race-wither x1 metta x7 ISBN x1 asia x1 racewme x1 durham x5 freemium x3 bezos x21 surp x1 headlines x5 e-books x50 bloomberg x3 homepage x1 pq-praise x1 collecting x3 GTD x3 70s x1 memex x2 hubris x4 satire x1 cussing x1 odd x2 buzzfeed x4 PETA x1 repercussions x3 switzerland x1 data-follies x4 radical-chic x1 camelot x1 CPMs x1 slow-burn x1 iteration x3 vonnegut x1 apartheid x2 popularity x2 solar x1 signal x3 stream x4 WASPs x1 fracking x4 HDC x1 wikipedia x2 opacity x1 unknowing x3 linkalicous x1 bill-murray x1 cost-benefit x1 SaaS x1 youth x1 milky-way x1 e-text x1 thin-skins x1 ancien-regime x1 mobsters x1 dixie x1 bedbugs x1 hashtags x2 weddings x1 moguls x2 geo x2 wandering x1 elasticity x1 chat x1 folksonomy x1 pinterest x2 yiddish x1 loop x1 middlebrow x1 20th-century x1 transience x1 content-sales x3 scams x2 kickstarter x1 mash-up x3 taglines x2 forking x3 peak-ads x3 pacino x1 DFW x1 the-triangle x1 portland x1 tool x3 b2b x1 cartoons x1 80s x1 soccer x1 iron-curtain x1 16 x1 Hillary x1 Chromebook x1 mavericks x1 smb x1 penance x1 South-Africa x1 sherlock-holmes x1 Zap x2 niche-dsp x1 disclosure x1 simonschuster x1 Maigret x1 audiobooks x1 ARPANET x1 jesus x1 stooges x1 oxymoron x3 revenge x1 curiosity x1 FUBAR x4 apprenticeship x1 didion x1 popova x3 hummingbird x2 blank-page x2 henry-blodget x3 bookmarks x2 NATO x1 hypocricy x2 FMCG x1 rand-paul x1 utopia x1 90s x1 displacement x1 assange x2 propaganda x1 oratory x1 PBS x1 TED x1 bricks x1 murdoch x1 quality x1 seventies x1 clive-thompson x1 asymmetry x1 lists x3 aol x1 huffpo x1 elegant x1 foursquare x1 medium x3 Tina-Brown x1 state-budgets x1 First-Amendment x3 recruiting x1 test x1 emergent x1 TDCS x1 klout x1 consulting x1 NSA x6 snowden x4 dematerialization x1 half-baked x1 etf x1 boomers x1 pogue x3 turn-around x1 winer x1 naive x1 triumphalism x1 population x1 poitras x2 1984 x1 Orwell x1 geeks x1 cannibalization x1 salmon x1 hmm x1 malaprops x1 comments x1 dumb x1 yhoo x0