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Drug shown to block artery fat takes a major step forward | News | The University of Aberdeen

In the latest study, funded by the University of Aberdeen’s Development Trust, researchers tested the success of Trodusquemine, on white blood cells taken from 30 healthy volunteers and 30 volunteers with coronary artery disease and atherosclerosis. They were able to see the same biochemical changes in the cells taken from people as they did in mice after the use of PTP1B inhibitor. When PTB1B levels are increased in the body, a series of events occur leading to white blood cells taking up oxidised cholesterol, which then turn them into foamy cells, that lead to fatty deposits within arteries and cause even more inflammation.

#stenosis #trodusquemine - abdn.ac.uk

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