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Frontiers | Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants

After 12 months of NK consumption, both the size of CCA-IMT and the size of the carotid artery plaque decreased significantly (from 1.33 to 1.04mm on average, P < 0.001). The size of the plaque decreased by up to 36%, suggesting that NK is very effective in improving/reducing carotid atherosclerosis (Table 4). The overall improvement rates in CCA-IMT and CPS are not as high as those in blood lipids, with approximately 2/3 and 77.7% of the participants showing improvement in CPS and CCA-IMT, respectively (Table 3). TABLE 4