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Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic
Nonlinear inverse associations of coffee, tea, and caffeine intake with the risk of new-onset CM were observed. Compared with nonconsumers or consumers of less than 100 mg caffeine per day, consumers of moderate amount of coffee (3 drinks/d) or caffeine (200-300 mg/d) had the lowest risk for new-onset CM, with respective hazard ratios (95% CIs) of 0.519 (0.417-0.647) and 0.593 (0.499-0.704). Multistate models revealed that moderate coffee or caffeine intake was inversely associated with risks of almost all developmental stages of CM, including transitions from a disease-free state to single cardiometabolic diseases and subsequently to CM. A total of 80 to 97 metabolites, such as lipid components within very low-density lipoprotein, histidine, and glycoprotein acetyls, were identified to be associated with both coffee, tea, or caffeine intake and incident CM.
Anti-Pharma Bus Tour; Rapamycin for Longevity? Hospital Forgives Debt After Pressure | MedPage Today
For a group of people trying to slow aging, a small weekly dose of rapamycin is part of their strategy. They use the drug off-label or purchase it from overseas. People interviewed by the Times said the drug brought mild health benefits, like weight loss, improved gum health, and fewer aches and pains.
"Longevity influencers" often cite a 2014 article in Aging Cell
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as evidence that rapamycin can extend life -- in mice -- by 20%. There's also been research assessing the anti-aging potential of rapamycin in yeast, worms, flies, and marmosets, which saw a 10% increase in lifespan, and a few looking at people, which had inconclusive results or aren't peer-reviewed yet. Scientists suspect any anti-aging benefits occur because rapamycin inhibits the mTOR complex, which may decrease inflammation and ramp up autophagy.
Reduced Body Flexibility Is Associated With Poor Survival in Middle‐Aged Men and Women: A Prospective Cohort Study
To the best of our knowledge, this is the first cohort study to
show that a reduced level of body flexibility—as assessed by
the Flexindex, a composite score of maximal passive ROM of 20
movements in seven major joints—is related to higher mortality
in a large middle-
aged cohort of men and women. By analyzing
death rates according Flexindex's data distribution, a consistent
pattern emerged among middle-
aged men and women, indicat-
ing a gradual and inverse relationship between Flexindex and
both natural and non-
COVID-
19 mortality during an average
follow-
up of nearly 13
years.
The association was most pronounced at the extremes of the
Flexindex score distribution [death rate%]—men: [P91–99] 7.8%
versus [P1–10] 21.2% and women: [P91–99] 2.0% versus [P1–10]
15.4%.—and remained significant when further sequentially ad-
justed for age, BMI and health status.
Cheers to Longevity: Couples Who Drink Together, Live Longer - Neuroscience News
Shared Drinking Habits Linked to Longevity: Couples who both drink alcohol tend to live longer compared to those with discordant drinking habits or who abstain altogether.
Impact on Relationship Quality: Concordant drinking couples report higher relationship satisfaction, potentially due to increased intimacy and shared activities.
Intermittent fasting makes fruit flies live longer — will it work for people? -- ScienceDaily
The researchers put their flies on one of four different schedules: 24-hour unrestricted access to food, 12-hour daytime access to food, 24-hour fasting following by 24-hour unrestricted feeding, or what the researchers called intermittent time-restricted fasting or iTRF (20 hours of fasting followed by a recovery day of unlimited feeding).
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Among the four eating schedules, only iTRF significantly extended the lifespan -- 18% for females and 13% for males.
And the timing of the 20-hour fast was critical: Lifespan increased only for flies that fasted at night and broke their fast around lunchtime. The lifespans of flies that instead fasted all day, eating only at night, did not change.
Artificial intelligence in longevity medicine | Nature Aging
In order for these tools to be adopted by clinicians and accepted by the medical community, they need to be integrated into the current framework of clinical practice, ranging from primary through to secondary prevention, treatment and monitoring. Such integration requires the convergence of modern AI and medicine through a symbiotic collaboration between clinicians, geroscientists and AI researchers. Physicians should be encouraged and have the chance to be involved in AI-based longevity research. At the same time, AI-powered longevity biotechnology and AI-based biomarker-driven science should be promoted and seek close clinical and metaclinical collaborations. Doctors first need to have the access to tailored, validated and credible education on AI-based biogerontology sciences, such as accredited courses, that would further allow longevity physicians to build their networks and ultimately create a separate medical discipline. A basic knowledge of AI-driven geroscience is essential to bring relevant scientific discoveries to trials, and study outcomes to the clinic.
Uric acid: What’s optimal? – Michael Lustgarten
Lycopene is found almost exclusively in tomatoes and watermelon. If these foods are related to my increasing levels of uric acid, if I ate less of them, I’d expect to see a corresponding decrease in uric acid. So, in 2019, I ate less of these foods, thereby reducing my average lycopene intake from 11,585 to 9,132 micrograms per day. How did that affect circulating levels of uric acid?
In 6 measurements for 2019, my average uric acid level was 4.6 mg/dL, a value that was significantly different (p=0.02) from the 2016-2018 average of 5.2 mg/dL. Whether eating less watermelon and tomatoes caused the decrease is unknown, but it’s good to know that uric acid can be potentially modified with dietary change!
Scientists see inner workings of enzyme telomerase, which plays key roles in aging, cancer: Detailed view of its core may lead to development of targeted drugs -- ScienceDaily
"We're now seeing not just the face of the clock, we're seeing how the components inside interact to make it work," said Juli Feigon, a professor of chemistry and biochemistry in the UCLA College and a senior author of the study. "At each step, we zoom in closer and see more and more details, and can now begin to deduce not just what the enzyme looks like, but also how it functions. Knowing that may lead to the development of new drugs that target specific parts of the enzyme."
Running as a Key Lifestyle Medicine for Longevity. - PubMed - NCBI
Running is a popular and convenient leisure-time physical activity (PA) with a significant impact on longevity. In general, runners have a 25%-40% reduced risk of premature mortality and live approximately 3 years longer than non-runners. Recently, specific questions have emerged regarding the extent of the health benefits of running versus other types of PA, and perhaps more critically, whether there are diminishing returns on health and mortality outcomes with higher amounts of running. This review details the findings surrounding the impact of running on various health outcomes and premature mortality, highlights plausible underlying mechanisms linking running with chronic disease prevention and longevity, identifies the estimated additional life expectancy among runners and other active individuals, and discusses whether there is adequate evidence to suggest that longevity benefits are attenuated with higher doses of running.
