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Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis | Journal of Neurology, Neurosurgery & Psychiatry

Forty-two pwMS were randomised, 34 completed the study (17/group). Leptin serum levels at 12 weeks were significantly lower in the iCR versus the control group (mean decrease −6.98 µg/dL, 95% CI: −28.02 to 14.06; p=0.03). Adherence to iCR was 99.5% and 97.2% at 6 and 12 weeks, respectively, and no serious AEs were reported. An increase in blood CD45RO+ regulatory T-cell numbers was seen after 6 weeks of iCR. Exploratory cognitive testing demonstrated a significant improvement in the Symbol Digit Modality Test Score in the iCR group at 12 weeks.

#inflamation #cognition #fasting #multiple-sclerosis #leptin - jnnp.bmj.com

Intermittent Fasting Shows Promise in Multiple Sclerosis | MedPage Today

Intermittent calorie restriction lowered leptin levels in a small trial of relapsing-remitting multiple sclerosis (MS). Leptin may have a pathogenic role in MS. Intermittent calorie restriction also showed cognitive benefits in an exploratory analysis.

#fasting #multiple-sclerosis #leptin - medpagetoday.com

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