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Keto Diet May Ease Multiple Sclerosis Symptoms - Neuroscience News
New research suggests the ketogenic diet could help manage multiple sclerosis (MS) by promoting the production of beneficial compounds in the gut. In a study, mice on a keto diet produced the ketone body β-hydroxybutyrate (βHB), which worked with gut bacteria to create immune-modulating metabolites. This interaction reduced inflammation and improved MS symptoms in mice.
Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial | JACC: Advances
Coronary plaque in metabolically healthy individuals with carbohydrate restriction-induced LDL-C ≥190 mg/dL on KETO for a mean of 4.7 years is not greater than a matched cohort with 149 mg/dL lower average LDL-C. There is no association between LDL-C and plaque burden in either cohort. (Diet-induced Elevations in LDL-C and Progression of Atherosclerosis [Keto-CTA]; NCT057333255)
Eating Meat Is Linked With Type 2 Diabetes, New Studies Suggest - The New York Times
Those with the highest heme iron consumption — mainly coming from eight to 10 servings of unprocessed red meat per week — were 26 percent more likely to develop Type 2 diabetes than those with the lowest consumption. They also had higher lipid levels, markers of insulin resistance and inflammation, and other compounds linked with Type 2 diabetes in their blood, the study revealed.
Can the Ketogenic Diet Treat Mental Illness? | MedPage Today
Though 3 patients were unable to adhere to the diet for more than 14 days, the researchers concluded that following the ketogenic diet for treatment-refractory mental illness was "feasible, well-tolerated, and associated with significant and substantial improvements in depression and psychosis symptoms and multiple markers of metabolic health."
More than 40% of patients experienced remission from their diagnosis, Ede said, and 64% left the hospital on less psychiatric medication than when they entered.
High Protein Diet Reduces Depression Symptoms - Neuroscience News
The results showed higher protein intake was associated with a reduction in symptoms of depression during the follow-up period.
Are high-protein total diet replacements the key to maintaining healthy weight? -- ScienceDaily
Subjects were then randomly assigned into one of two groups: one group was fed the high-protein total diet replacement, which consisted of 35% carbohydrate, 40% protein, and 25% fat. The second group, the control group, was fed a diet with the same number of calories, but consisting of 55% carbohydrate, 15% protein, and 30% fat, a typical North American dietary pattern. Participants received the prescribed diets for a 32-hour period while inside a metabolic chamber.
Compared to the standard North American dietary pattern, the findings of this inpatient metabolic balance study revealed that the high-protein total diet replacement led to "higher energy expenditure, increased fat oxidation, and negative fat balance." In particular, the results of the study provide further evidence that a calorie is not just a calorie. That is, a diet with a higher proportion of protein might lead to an increase in energy expenditure and fat oxidation compared to a diet consisting of the same number of calories, but with a lower proportion of protein as well as a higher proportion of carbohydrate or fat.
On the keto diet? Ditch the cheat day: Just one dose of carbohydrates can damage blood vessels -- ScienceDaily
For their test, the researchers recruited nine healthy young males and had them consume a 75-gram glucose drink before and after a seven-day high fat, low carbohydrate diet. The diet consisted of 70 per cent fat, 10 per cent carbohydrates and 20 per cent protein, similar to that of a modern ketogenic diet.
"We were originally looking for things like an inflammatory response or reduced tolerance to blood glucose," says Durrer. "What we found instead were biomarkers in the blood suggesting that vessel walls were being damaged by the sudden spike in glucose."
Little says the most likely culprit for the damage is the body's own metabolic response to excess blood sugar, which causes blood vessel cells to shed and possibly die.
"Even though these were otherwise healthy young males, when we looked at their blood vessel health after consuming the glucose drink, the results looked like they might have come from someone with poor cardiovascular health," adds Little. "It was somewhat alarming."
Diet's effect on gut bacteria could play role in reducing Alzheimer's risk -- ScienceDaily
In a small pilot study, the researchers identified several distinct gut microbiome signatures -- the chemicals produced by bacteria -- in study participants with mild cognitive impairment (MCI) but not in their counterparts with normal cognition, and found that these bacterial signatures correlated with higher levels of markers of Alzheimer's disease in the cerebrospinal fluid of the participants with MCI.
Through cross-group dietary intervention, the study also showed that a modified Mediterranean-ketogenic diet produced changes in the gut microbiome and its metabolites that correlated with reduced levels of Alzheimer's markers in the members of both study groups.
Ketogenic Diet for Schizophrenia: Clinical Implication
Abnormal glucose and energy metabolism and mitochondrial functioning are emerging as important pathophysiological mechanism in schizophrenia. Therapeutic ketogenic diet shows promise to interfere with these processes resulting in the restoration of normal synaptic communication and alleviation of the devastating psychiatric symptoms. Furthermore, because of the impact of ketogenic diet on systemic metabolism, it is possible that the metabolic features and cardiovascular risk typical of patients with chronic schizophrenia can be addressed by this dietary intervention. However, more research is needed both at preclinical level and in the form of controlled clinical trials before ketogenic diet can take its place in the mainstream of the treatment and management of schizophrenia.
On the keto diet? Ditch the cheat day: Just one dose of carbohydrates can damage blood vessels -- ScienceDaily
"Since impaired glucose tolerance and spikes in blood sugar levels are known to be associated with an increased risk in cardiovascular disease, it made sense to look at what was happening in the blood vessels after a sugar hit."
For their test, the researchers recruited nine healthy young males and had them consume a 75-gram glucose drink before and after a seven-day high fat, low carbohydrate diet. The diet consisted of 70 per cent fat, 10 per cent carbohydrates and 20 per cent protein, similar to that of a modern ketogenic diet.
"We were originally looking for things like an inflammatory response or reduced tolerance to blood glucose," says Durrer. "What we found instead were biomarkers in the blood suggesting that vessel walls were being damaged by the sudden spike in glucose."
Little says the most likely culprit for the damage is the body's own metabolic response to excess blood sugar, which causes blood vessel cells to shed and possibly die.
"Even though these were otherwise healthy young males, when we looked at their blood vessel health after consuming the glucose drink, the results looked like they might have come from someone with poor cardiovascular health," adds Little. "It was somewhat alarming."
