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Do You Have Restless Legs Syndrome (RLS)? Treatment Advice Has Changed > News > Yale Medicine

Specifically, the academy changed its previous strong recommendation for the use of dopamine agonists to a conditional recommendation against them in response to clinical trials, longitudinal studies, and the experience of doctors in the field showing the drugs cause augmentation. This affects medications including the drugs pramipexole (Mirapex®) and ropinirole (Requip®) among others. “What really moved the needle on these drugs is an increase in the number of people who take them and develop augmentation,” Dr. Koo says. “It takes years to develop augmentation, but many of the patients who were started on these medicines in the early 2000s, when they were considered breakthrough medications for RLS, have been on them now for 20-plus years.”

#dopamine #augmentation - yalemedicine.org

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