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Link between autoimmune disorders and psychosis confirmed in new study
But rheumatoid arthritis and ankylosing spondylitis are also characterised by higher levels of inflammation, so this would not explain the negative relationships we found with these disorders. Although all autoimmune disorders activate the body’s immune system, the exact response differs depending on the disorder. This might go some way to explaining why we found different relationships for individual autoimmune disorders, and suggests that inflammation cannot be the only mechanism.
'Mono' virus linked to 7 serious diseases: Epstein-Barr virus may affect health in more ways than known -- ScienceDaily
The new paper shows that seven seemingly unrelated disease states actually share a common set of abnormal transcription factors, each affected by the EBNA2 protein from the Epstein-Barr virus. When these EBNA2-related clusters of transcription factors attach themselves to one portion of the genetic code, the risk of lupus appears to rise. When those same transcription factors land on another part of the code, the risk of multiple sclerosis appears to rise. And so on.
"Normally, we think of the transcription factors that regulate human gene expression as being human," Kottyan says. "But in this case, when this virus infects cells, the virus makes its own transcription factors, and those sit on the human genome at lupus risk variants (and at the variants for other diseases) and that's what we suspect is increasing risk for the disease."
Knee Arthritis Has Doubled... And It’s Not Because of Running | Runner's World
Even accounting for age and BMI, knee osteoarthritis was still roughly twice as common for people born after World War II than it was for people born before it.