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Lipoprotein (a) Meaning and How Does it Impact My Heart Health? | American Heart Association

High Lp(a) numbers of 50 mg/dL (125 nmols/L) or higher promote clotting and inflammation, significantly increasing risk of heart attack, stroke, aortic stenosis and peripheral artery disease. This is especially true for those with coronary heart disease or familial hypercholesterolemia, or FH, an inherited condition that affects the body’s ability to process LDL “bad” cholesterol. Lp(a) can accumulate in the walls of blood vessels, forming plaques similarly to LDL cholesterol. These plaques can block blood flow to vital organs such as the heart, brain, kidneys, lungs, and other parts of the body, leading to conditions like heart attacks, strokes, and other cardiovascular diseases.