Recent quotes:

Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis | Nature Cardiovascular Research

Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the advance of lipid-lowering therapies and anti-hypertensive agents, the residual risk of an atherosclerotic event remains high, and developing therapeutic strategies has proven challenging. This is due to the complexity of atherosclerosis with a spatial interplay of multiple cell types within the vascular wall. In this study, we generated an integrative high-resolution map of human atherosclerotic plaques combining single-cell RNA sequencing from multiple studies and spatial transcriptomics data from 12 human specimens with different stages of atherosclerosis. Here we show cell-type-specific and atherosclerosis-specific expression changes and spatially constrained alterations in cell–cell communication. We highlight the possible recruitment of lymphocytes via ACKR1 endothelial cells of the vasa vasorum, the migration of vascular smooth muscle cells toward the lumen by transforming into fibromyocytes and cell–cell communication in the plaque region, indicating an intricate cellular interplay within the adventitia and the subendothelial space in human atherosclerosis.
#heart #LAD #lipids - nature.com

Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention - ScienceDirect

Previous studies have demonstrated a cholesterol-lowering effect of red yeast rice (RYR) supplements which contained 5 to 10 mg of monacolin K. We hypothesized that the intake of a low monacolin K dose may likewise reduce low-density lipoprotein–cholesterol (LDL-C) and other plasma lipids.
#LAD #RYR - sciencedirect.com

Will drinking green tea reduce my risk of heart attacks and strokes? - BHF

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said: “Our bodies are very good at breaking down EGCG, so swapping your cuppa for green tea is unlikely to make a big difference with respect to your heart health. “But by engineering the molecule slightly, we might be able to make new medicines to treat heart attack and stroke.”
#LAD - bhf.org.uk