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Losing My Religion Meaning

This title and tag line have thrown some interpreters, but Georgia-born Stipe explained that it’s a Southern expression used when “something has pushed you so far that you would lose your faith over it. Something has pushed you to the nth degree.” In other words, losing your religion is being at your rope’s end; it’s being on the brink. The phrase and the song, therefore, are not really about religion at all, which Stipe is emphatic about. “Some people still think that it's a song about religion; it's not. It's just a song about having a crush."
#losing-my-religion - shmoop.com