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Should I Leave My Husband? The Lure of Divorce
To cope with the stress, I asked my psychiatrist to increase the dosage of the antidepressant I’d been on for years. Sometime around then, I started talking too fast and drinking a lot.
Cancer drugs don't always work as intended, researchers warn -- ScienceDaily
In a new paper recently published in the journal Science Translational Medicine, a team of researchers led by Sheltzer and researchers Ann Lin and Chris Giuliano, detail how the "mechanism of action" of the 10 drugs were mischaracterized, just like MELK.
"The idea for many of these drugs is that they block the function of a certain protein in cancer cells. And what we showed is that most of these drugs don't work by blocking the function of the protein that they were reported to block," Sheltzer explained. "So that's what I mean when I talk about mechanism of action."
All 10 of the drugs are currently being tested in clinical trials and involve about 1000 human cancer patients. And while they do appear capable of killing cancer cells, it's just not in the way researchers had thought. So how can this be?
"In some sense, this is a story of this generation's technology," Sheltzer said.
Comparative Accuracy of Diagnosis by Collective Intelligence of Multiple Physicians vs Individual Physicians. | Medical Education and Training | JAMA Network Open | JAMA Network
Using the top 3 diagnoses given by each user to adjudicate solutions, the diagnostic accuracy of all users was 62.5% (95% CI, 60.1%-64.9%). The accuracy of individual residents and fellows was 65.5% (95% CI, 63.1%-67.8%) compared with 55.8% for medical students (95% CI, 53.4%-58.3%; P < .001 for difference vs residents and fellows by z test for proportions) and 63.9% for attending physicians (95% CI, 61.6%-66.3%; P = .10 for difference vs residents and fellows).
The frequency of diagnostic errors in outpatient care: estimations from three large observational studies involving US adult populations | BMJ Quality & Safety
Data sources included two previous studies that used electronic triggers, or algorithms, to detect unusual patterns of return visits (primary care study) or lack of follow-up of abnormal clinical findings for colorectal cancer (CRC) (colon cancer study), both suggestive of diagnostic errors.4 ,6 A third study examined consecutive cases of lung cancer in two institutions (lung cancer study).5 In all three studies, diagnostic errors were confirmed through chart review and defined as missed opportunities to make a timely or correct diagnosis based on available evidence. The criteria for diagnostic errors were comparable across the three studies and excluded atypical presentations and appropriate decisions to watch and wait.
Worldwide estimates suggest that nearly 1 in 2 children with cancer are left undiagnosed and untreated -- ScienceDaily
"Our model suggests that nearly one in two children with cancer are never diagnosed and may die untreated," says study author Zachary Ward from the Harvard T.H. Chan School of Public Health, USA. "Accurate estimates of childhood cancer incidence are critical for policy makers to help them set healthcare priorities and to plan for effective diagnosis and treatment of all children with cancer. While under-diagnosis has been acknowledged as a problem, this model provides specific estimates that have been lacking."
Are Emotional Disorders Really Disorders of Love? - Mad In America
As family members, therapists or doctors, what if we never again promoted or prescribed drugs as a “treatment” because they ultimately impair our frontal lobes and hence our ability to love? Could we jettison all our ugly, cookie cutter, unloving diagnoses—ADHD, conduct disorder, obsessive-compulsive disorder, panic disorder, major depressive disorder, bipolar disorder, schizophrenia, and PTSD? Could we instead help others to discover where their loving engagement with life was discouraged or lost and how to revive it or even to experience it for the first time?
Looking for a cure...
At first, fatigue, brain fog, and body aches made it hard to do my job some days; then every day felt like a battle with the flu. Constant acid reflux, bloating, gas, and constipation became an accepted part of life. Next came burning and tingling in my hands, rashes, joint and chest pain, heart palpitations, and poor sleep. But I kept working through it, for years, until I simply no longer could and I had to stop my medical practice.
What ensued was a years-long journey of trying everything under the sun to overcome what turned out to be fibromyalgia and chronic Lyme Disease, both of which I blamed for all of my digestive symptoms. It made sense at the time—nausea and loss of appetite are common among Lyme sufferers, and half of people with fibromyalgia experience IBS symptoms. But after much research and personal trial and error, I realized that it wasn’t that simple. Instead, the same factors that left me susceptible to chronic illness were also to blame for my gut symptoms: Nothing would improve until I addressed those underlying causes.
Since then, I’ve discovered that the majority of digestive health issues—including IBS, gastroesophageal reflux disease (GERD), leaky gut, chronic constipation, food sensitivities and allergies, and more—can be traced back to the same four factors that were making me sick. I call them gut disruptors, and if you feel like you’ve tried everything to overcome your gut issues, getting to know them could be the secret to finally restoring your digestive and overall health.
